期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 9, 期 11, 页码 1847-1861出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2013.1686
关键词
pH-Responsive Copolymers; Self-Assembly; Drug Delivery; Sulfobetaine; Internalization
资金
- National Natural Science Foundation of China [51073103, 51273125]
pH-sensitive micelles are considered promising carriers for tumor targeted drug delivery. In this study, novel pH-sensitive star-shape copolymers of amphiphilic poly(epsilon-caprolactone)-b-poly(N, N-diethylaminoethyl methacrylate)-rpoly(N-(3-sulfopropy1)-N-methacryloxyethy-N, N-diethylammoniumbetaine) (4sPCLDEAS) are designed and synthesized with the combination of ring opening polymerization (ROP) and atom radical transferpolymerization (ATRP). The structure of the copolymers is characterized by proton nuclear magnetic resonance spectra ((HNMR)-H-1). The poly(N-(3-sulfopropyI)-Nmethacryloxyethy-N, N-diethylammoniumbetaine) segment is used instead of poly(ethylene glycol) (PEG) as hydrophilic block in the copolymers to form polymeric micelles. The micelles present spherical shape, narrow size distribution, and are reponsive to the acidity. The CMC of the micelles is as low as 1 x 10(-3) mg mL(-1). Doxorubin (DOX) is efficiently encapsulated in the micelles and the drug release is pH dependant. The cytotoxicity as well as the intracellular drug delivery of the micelles are investigated. The micelles are nontoxic to human cervical carcinoma (Hela) cells. The DOX-loaded micelles are internalized in Hela cells efficiently, which are better than that of hydrophilic doxorubicin hydrochloride (DOX HCI). These pH-sensitive micelles are potential promising carriers for anti-cancer drug delivery.
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