期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 8, 期 1, 页码 90-97出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2012.1371
关键词
Insulin-Phospholipid Complex (IPC); Self-Nanoemulsifying Drug Delivery Systems (SNEDDS); MDCK Monolayer; Diabetic Models; Enhanced Oral Absorption
资金
- National Basic Research Program of China [2009CB903300]
- Sichuan Province Science and technology support program [2009SZ0141]
Self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of insulin after oral administration, where insulin was complexed with phospholipid to achieve a better liposolubility in the form of insulin-phospholipid complex (IPC). IPC was formulated into the oil phase of SNEDDS by solvent-evaporation method. The formula of IPC-SNEDDS was optimized and characterized. Data showed that SNEDDS as a drug vehicle did not exhibit an obvious inhibition over MDCK cells, and it can facilitate the transport of IPC across MDCK cell monolayer. IPC-SNEDDS could enhance the absorption of insulin after oral administration and yielded a pronounced hypoglycemic effect on diabetic Wistar rats. All these suggested that IPC-SNEDDS has a great potential for oral delivery of insulin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据