期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 7, 期 1, 页码 100-101出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2011.1221
关键词
TiO(2) Nanoparticles; Human Keratinocyte Cells; Skin
资金
- CSIR, New Delhi [NWP35, SIP-08]
- Department of Science and Technology-UK India Education and Research Initiative (UKIERI) Research [DST/INT/UKIERI/SA/P-10/2008]
- DST-NSTI [SR/S5/NM-01/2007]
- University Grant Commission (UGC), New Delhi
Titanium dioxide nanoparticles (TiO(2) NPs) are the most commonly used metal oxide NPs in various industrial and commercial products. The present study has demonstrated a significant cellular uptake of TiO(2) NPs in the human keratinocyte cells (HaCaT) using transmission electron microscopy and flow cytometry. The data exhibited a significant (p < 0.05) concentration dependent decrease in cell viability and glutathione with concomitant increase in lipid peroxidation and reactive oxygen species. The increased oxidative stress further leads to apoptosis after 48 h of exposure. Our study demonstrates oxidative stress mediated apoptosis in human keratinocyte cells exposed to TiO(2) NPs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据