期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 7, 期 1, 页码 135-136出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2011.1237
关键词
Visceral Leishmaniasis; Doxorubicin; Targeting; Microparticles
Visceral leishmaniasis (VL) is the most severe of all the forms of leishmaniasis and usually lethal if untreated. The present work aimed to develop and characterize doxorubicin loaded mannan conjugated microparticles against experimental visceral leishmaniasis for selective and targeted delivery of doxorubicin to the macrophages of liver and spleen for the effective chemotherapy of VL. Macrophage targeting using doxorubicin loaded PLGA-microparticles would certainly improve the chemotherapy with reduced side effects against VL.
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