期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 6, 期 2, 页码 176-180出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2010.1112
关键词
Nanoparticles; Two-Photon Fluorescence; PEG; Dye; Cancer Cells
资金
- CNRS
- Region Languedoc Roussillon
New nanotools for the imaging of cancer cells have been synthesized. Two-photon dye-doped 3-aminopropyltriethoxysilane-grafted mesoporous silica nanoparticles (MSN) have been grafted with folic acid (FA) functionalized PEG groups. Amine-PEG groups were first reacted with an activated ester derivative of FA. A mixture of FA- and hydroxyl-PEG has then been reacted with the amino groups at the surface of the particles. Cell culture experiments performed with MCF7 and HeLa cancer cells demonstrated that these functionalized MSN showed a low cytotoxicity even after a 24 hours incubation time at high concentrations. These modified MSN are promising for applications in the field of two-photon imaging and their potentiality for photodynamic therapy is currently being investigated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据