4.5 Article

Analysis of Protein Physical Stability in Lipid Based Delivery Systems-The Challenges of Lipid Drug Delivery Systems

期刊

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 5, 期 4, 页码 401-408

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AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2009.1049

关键词

Lipid Based Drug Delivery Systems; Protein; Peptide; Water-in-Oil Emulsion; SLN; FTIR; DSC; Interfaces; Protein Physical Stability; Lysozyme

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Lipid based systems are a promising delivery system for many drug molecules, including labile compounds such as peptides and proteins. However, in the development of these systems the effect on the physical stability is rarely taken into account. Physical changes are often correlated with changes in biological activity but are generally much easier to assess. The present paper illustrates the use of a combination of techniques, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and intrinsic tryptophan fluorescence, to determine structural changes of proteins in lipid based systems such as solid lipid nanoparticles and emulsions.

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