期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 102, 期 8, 页码 1689-1699出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.b.33146
关键词
fluid shear stress; cellular growth; numerical modeling; titanium porous structures; additive manufacturing
资金
- Research Complex at Harwell
- EPSRC [EP/IO2249X/1]
- EPSRC [EP/I02249X/1, EP/I020861/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I02249X/1, EP/I020861/1] Funding Source: researchfish
Bone augmentation implants are porous to allow cellular growth, bone formation and fixation. However, the design of the pores is currently based on simple empirical rules, such as minimum pore and interconnects sizes. We present a three-dimensional (3D) transient model of cellular growth based on the Navier-Stokes equations that simulates the body fluid flow and stimulation of bone precursor cellular growth, attachment, and proliferation as a function of local flow shear stress. The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures. The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates. This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements. (C) 2014 Wiley Periodicals, Inc.
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