期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 103, 期 2, 页码 457-463出版社
WILEY
DOI: 10.1002/jbm.b.33211
关键词
polyesteramide amino acid; coating; suture; foreign body; inflammation
资金
- Rebecca Q. Morgan Foundation
- Joseph and Theresa Wood
Sutures elicit an inflammatory response, which may impede the healing process and result in wound complications. We recently reported a novel family of biocompatible, biodegradable polymers, amino acid-based poly(ester amide)s (AA-PEA), which we have shown to significantly attenuate the foreign body inflammatory response in vitro. Two types of AA-PEA (Phe-PEA and Arg-Phe-PEA) were used to coat silk or plain-gut sutures, which were implanted in the gluteus muscle of C57BL/6 mice, while the uncoated control sutures were implanted in the contralateral side. After 3, 7, 14, and 28 days the mean area of inflammation surrounding the sutures was compared. Phe-PEA coating of silk sutures significantly decreased inflammation compared with noncoated controls (67.8 +/- 17.4% after 3d [p=0.0014], 51.6 +/- 7.2% after 7d [p<0.001], and 37.3 +/- 8.3% after 28d [p=0.0001]) when assessed via analysis of photomicrographs using digital image software. Phe-PEA coated plain-gut sutures were similarly assessed and demonstrated a significant decrease in the mean area of inflammation across all time points (54.1 +/- 8.3% after 3 d, 41.4 +/- 3.9% after 7 d, 71.5 +/- 8.1% after 14 d, 78.4 +/- 8.5%, and after 28 d [all p<0.0001]). Arg-Phe-PEA coated silk demonstrated significantly less inflammation compared to noncoated controls (61.3 +/- 9.4% after 3 d, 44.7 +/- 4.7% after 7 d, 19.6 +/- 8%, and 38.3 +/- 6.8% after 28 d [all p<0.0001]), as did coated plain-gut (37.4 +/- 8.3% after 3 d [p=0.0004], 55.0 +/- 7.8% after 7 d [p<0.0001], 46.0 +/- 4.6% after 14 d [p<0.0001], and 59.0 +/- 7.9% after 28 d [p<0.0001]). Both Phe-PEA and Arg-Phe-PEA coatings significantly decrease the inflammatory response to sutures in vivo for up to 28 days. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 457-463, 2015.
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