期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 102, 期 3, 页码 619-634出版社
WILEY
DOI: 10.1002/jbm.b.33030
关键词
scaffolds; meniscus; regenerative medicine; tissue engineering
资金
- Department of Health [HTD 430] Funding Source: Medline
- EPSRC [EP/J017620/1, EP/F043872/1, EP/I019103/1, EP/K029592/1, EP/G012172/1, EP/G032483/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G012172/1, EP/J017620/1, GR/S63892/01, EP/F043872/1, EP/G032483/1, EP/K029592/1, EP/I019103/1] Funding Source: researchfish
- National Institute for Health Research [HTD 430, NF-SI-0611-10096] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [HTD 430] Funding Source: National Institutes of Health Research (NIHR)
The meniscus plays an important role in the biomechanics and tribology of the knee joint. Damage to or disease of the meniscus is now recognized to predispose to the development of osteoarthritis. Treatment of meniscal injury through arthroscopic surgery has become one of the most common orthopedic surgical procedures, and in the United States this can represent 10 to 20% of procedures related to the knee. The meniscus has a limited healing capacity constrained to the vascularized periphery and therefore, surgical repair of the avascular regions is not always feasible. Replacement and repair of the meniscus to treat injuries is being investigated using tissue engineering strategies. Promising as these approaches may be, there are, however, major barriers to overcome before translation to the clinic. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 619-634, 2014.
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