期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 102, 期 1, 页码 173-180出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.b.32993
关键词
morselized allograft bone; tobramycin; impregnation; osseointegration; implant fixation
资金
- National Institutes of Health (NIH) [AR-42051]
- Danish Rheumatism Association, DK
- Elisabeth og Karl Ejnar Nis-Hanssens Mindelegat
Clinical trials have used antibiotic impregnated impacted bone allograft in revisions of infected arthroplasties. By this method high local antibiotic concentration and good control of infection was achieved. Toxicity studies, however, suggest that high local antibiotic concentration can impair osteoblast replication. We therefore asked whether impregnating morselized allograft bone with different quantities of tobramycin before impaction would impair implant fixation. We implanted three cylindrical (10 mm x 6 mm) porous-coated titanium implants into the distal femurs of 12 dogs. The implants were surrounded by a circumferential gap of 2.5 mm into which a standardized volume of morselized allograft bone, with or without tobramycin, was impacted. In each animal, the bone graft was impregnated with either 0 mg (control), 50 mg (low dose), or 200 mg (high dose) of tobramycin per 1 mL of bone graft. At the end of the 4 weeks experimental period, the implants with surrounding bone were evaluated by histomorphometric analysis and mechanical push-out test. We found no difference between the treatment groups regarding new bone formation, bone graft resorption, or implant fixation. There was, however, a tendency toward a decrease in implant fixation with higher tobramycin dose. The present study is unable to provide evidence on whether the use of topical tobramycin with allograft is safe or whether it indeed can impair implant fixation. The tendency toward an impaired implant fixation warrants further preclinical studies. Its current clinical use should be weighed against its possible positive effects on preventing infection in complicated revisions. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 173-180, 2014.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据