Evaluation of Substrates for 90 degrees Peel Adhesion-A Collaborative Study. II. Transdermal Drug Delivery Systems

In a previous study on peel adhesion for medical tapes, it was shown that a stainless steel (SS) substrate better discriminated among medical tapes than a high-density polyethylene (HDPE) substrate. The objective of this study was to determine if a SS substrate would also better distinguish among transdermal drug delivery systems (TDDSs). Five TDDSs (Vivelle Dot (R), Climara (R), Catapres-TTS (R), Duragesic (R)), and Mylan Fentanyl) were evaluated on three different substrates (SS, HDPE, and human cadaver skin). All measurements were made using a dwell time of similar to 3 min, a peel angle of 90 degrees, and a peel speed of 300 mm/min. Differences among TDDSs were greater for SS than for HDPE, using the F statistic for testing for differences among TDDSs means as a measure of heterogeneity, thereby indicating greater discrimination by SS. (c) 2008 Wiley Periodicals, Inc.*J Biomed Maier Res Part B: Appl Biomater 88B: 61-65, 2009