期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 103, 期 3, 页码 969-980出版社
WILEY
DOI: 10.1002/jbm.a.35240
关键词
titanium surface modifications; calcium ions; coagulation; osseointegration; plasma rich in growth factors
资金
- Ministry of Science and Innovation of the Spanish government (MICINN) [CEN-20072018]
The clinical success of load bearing dental and orthopedic implants relies on adequate osseointegration. Because of its favorable properties, titanium is generally considered as the material of choice. Following implant placement, titanium surfaces establish an ionic equilibrium with the surrounding tissues in which calcium plays major roles. Calcium is a cofactor of the coagulation cascade that mediates plasma protein adsorption and intervenes in a number of other intra and extracellular processes relevant for bone regeneration. In this study, titanium surfaces were modified with calcium ions (Ca2+ surfaces) and their responses to in vitro and in vivo models were analyzed. Unlike unmodified surfaces, Ca2+ surfaces were superhydrophilic and induced surface clot formation, platelet adsorption and activation when exposed to blood plasma. Interestingly, in vivo osseointegration using a peri-implant gap model in rabbit demonstrated that Ca2+ surfaces significantly improved peri-implant bone volume and density at 2 weeks and bone implant contact at 8 weeks as compared to the unmodified controls. The combination of Ca2+ surfaces with plasma rich in growth factors produced significantly more bone contact already at 2 weeks of implantation. These findings suggest the importance of the provisional matrix formation on tissue integration and highlight the clinical potential of Ca2+ titanium surfaces as efficient stimulators of implant osseointegration. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 969-980, 2015.
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