期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 103, 期 6, 页码 2172-2175出版社
WILEY
DOI: 10.1002/jbm.a.35368
关键词
electroactive polymer; stem cell; osteogenesis; dynamic conditions
资金
- FEDER funds through the Programa Operacional Fatores de Competitividade-COMPETE
- FCT-Fundacao para a Ciencia e a Tecnologia [PTDC/CTM-NAN/112574/2009, PEST-C/FIS/UI607/2014]
- Matepro-Optimizing Materials and Processes [NORTE-07-0124-FEDER-000037]
- Programa Operacional Regional do Norte under the Quadro de Referencia Estrategico Nacional (QREN), through the Fundo Europeu de Desenvolvimento Regional (FEDER) [ON.2-O Novo Norte]
- FCT [SFRH/BPD/90870/2012, SFRH/BPD/64958/2009, SFRH/BPD/97739/2013]
- Academy of Finland [136288, 256931]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/64958/2009, Incentivo/FIS/UI0607/2014, PTDC/CTM-NAN/112574/2009] Funding Source: FCT
- Academy of Finland (AKA) [256931, 256931] Funding Source: Academy of Finland (AKA)
This work reports on the influence of the substrate polarization of electroactive -poly(vinylidene fluoride) (-PVDF) on human adipose stem cells (hASCs) differentiation under static and dynamic conditions. hASCs were cultured on different -PVDF surfaces (non-poled and poled -) adsorbed with fibronectin and osteogenic differentiation was determined using a quantitative alkaline phosphatase assay. Poled - -PVDF samples promote higher osteogenic differentiation, which is even higher under dynamic conditions. It is thus demonstrated that electroactive membranes can provide the necessary electromechanical stimuli for the differentiation of specific cells and therefore will support the design of suitable tissue engineering strategies, such as bone tissue engineering. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2172-2175, 2015.
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