期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 103, 期 1, 页码 16-24出版社
WILEY
DOI: 10.1002/jbm.a.35138
关键词
electrospinning; nanofibers; curcumin; multidrug resistant organism
资金
- Council of Scientific and Industrial Reasearch (CSIR), Government of India [09/468(432)/2011]
Curcumin loaded poly(2-hydroxy ethyl methacrylate) p(HEMA) nanofiber were produced using electrospinning method and characterized. The nanofibrous scaffold supports good cell growth, attachment and retains its original morphology. Sustained and controlled release pattern of curcumin seen to be efficient against infectious disease caused by multidrug resistant organisms. Antibacterial activity of curcumin against Methicillin resistant staphylococcus aureus (MRSA) and extended spectrum lactamase (ESBL) proved to be a good alternate herbal compound for antibiotics. Hence the results indicate p(HEMA) nanofiber loaded with curcumin have potential to use as patch in wound healing of infectious disease caused by multidrug resistant organisms and excellent drug delivery vessel. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 16-24, 2015.
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