期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 103, 期 6, 页码 2141-2149出版社
WILEY
DOI: 10.1002/jbm.a.35358
关键词
implant infection; local drug delivery; degradable implant coating; bacterial biofilm; layered double hydroxides
资金
- Higher Education Commission of Pakistan
- German Academic Exchange Service (DAAD), Germany
- German Research Foundation (DFG) within the Collaborative Research Centre [SFB 599]
As an alternative to degradable organic coatings the possibility of using layered double hydroxides (LDHs) to generate implant coatings for controlled drug delivery was evaluated in vivo and in vitro. Coatings prepared from LDH suspensions dissolved slowly and appeared compatible with cultured cells. LDH coatings loaded with an antibiotic resulted in antibacterial effects in vitro. The LDH coating prolonged the drug release period and improved the proliferation of adherent cells in comparison to pure drug coatings. However, during incubation in physiological solutions the LDH coatings became brittle and pieces occasionally detached from the surface. For stress protection porous titanium implants were investigated as a substrate for the coatings. The pores prevented premature detachment of the coatings. To evaluate the coated porous implants in vivo a mouse model was established. To monitor bacterial infection of implants noninvasive in vivo imaging was used to monitor luminescently labeled Pseudomonas aeruginosa. In this model porous implants with antibiotic-loaded LDH coatings could antagonize bacterial infections for over 1 week. The findings provide evidence that delayed drug delivery from LDH coatings could be feasible in combination with structured implant surfaces. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2141-2149, 2015.
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