期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 102, 期 11, 页码 3803-3812出版社
WILEY
DOI: 10.1002/jbm.a.35050
关键词
tissue engineering; 3D scaffolds; nanostructured surface; osteoblasts
资金
- Australian Research Council
- Advanced Manufacturing Cooperative Research Centre (AMCRC)
- AMCRC
Silica nanoparticles were applied onto the fiber surface of an interbonded three-dimensional polycaprolactone fibrous tissue scaffold by an electrostatic layer-by-layer self-assembly technique. The nanoparticle layer was found to improve the fiber wettability and surface roughness. Osteoblast cells were cultured on the fibrous scaffolds to evaluate the biological compatibility. The silica nanoparticle coated scaffold showed enhanced cell attachment, proliferation, and alkaline phosphatase activities. The overall results suggested that interbonded fibrous scaffold with silica nanoparticulate coating could be a promising scaffolding candidate for various applications in bone repair and regeneration. (C) 2013 Wiley Periodicals, Inc.
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