期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 102, 期 5, 页码 1467-1477出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.34821
关键词
glycerol; degradable polymers; citric acid; polyester; controlled drug release
资金
- Alcoa Foundation
- National Institutes of Health Ruth L. Kirschstein National Research Service Award [T32 AR007505]
A new biomaterial, a degradable thermoset polymer, was made from simple, economical, biocompatable monomers without the need for a catalyst. Glycerol and citric acid, nontoxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90 to 150 degrees C. Consistent with a condensation reaction, water was determined to be the primary byproduct. The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and ratio between glycerol and citric acid. Also, the amount of crosslinking was inversely proportional to the rate of degradation. As a proof-of-principle for drug delivery applications, gentamicin, an antibiotic, was incorporated into the polymer with preliminary evaluations of antimicrobial activity. The polymers incorporating gentamicin had significantly better bacteria clearing of Staphylococcus aureus compared to non-gentamicin gels for up to 9 days. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1467-1477, 2014.
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