期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 102, 期 10, 页码 3379-3392出版社
WILEY
DOI: 10.1002/jbm.a.35010
关键词
polycaprolactone; bone scaffolds; solvent casting/particulate leaching method; polymer leaching method; dual leaching method
资金
- Thailand Research Fund (TRF) [DBG5280015]
- Royal Golden Jubilee Ph.D. Program (doctoral scholarship)
- Integrated Innovation Academic Center: IIAC [RES_01_54_63]
- Chulalongkorn University Centenary Academic Development Project
- Chulalongkorn University
- Petroleum and Petrochemical College (PPC), Chulalongkorn University
- National Center of Excellence on Petrochemical and Materials Technology (PETROMAT), Thailand
- Department of Anatomy, Faculty of Dentistry, Chulalongkorn University
Sodium chloride and polyethylene glycol (PEG) were used as water-soluble porogens for the formation of porous polycaprolactone (PCL) scaffolds. The main purpose was to prepare and evaluate in vitro efficacy of highly interconnected, three-dimensional, porous polymeric scaffolds, as obtained from the combined particulate and polymer leaching techniques. Microscopic analysis confirmed the high interconnectivity of the pores and relatively uniform pore size of 378-435 mu m. The PCL scaffolds were further characterized for their density and pore characteristics, water absorption and flow behaviors, and mechanical properties and the potential for their use as bone scaffolding materials was evaluated in vitro using mouse calvaria-derived preosteoblastic cells (MC3T3-E1). Evidently, the use of PEG as the secondary porogen not only improved the interconnectivity of the pore structures but also resulted in the PCL scaffolds that exhibited much better support for the proliferation and differentiation of the cultured bone cells. (C) 2013 Wiley Periodicals, Inc.
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