期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 101, 期 11, 页码 3266-3277出版社
WILEY
DOI: 10.1002/jbm.a.34636
关键词
cellulose; chitosan; hydroxyapatite; antimicrobial activity; bone tissue engineering
资金
- National Institute of General Medical Sciences of the National Institutes of Health [R15GM099033]
Hydroxyapatite (HAp) is often used as a bone-implant material because it is biocompatible and osteoconductive. However, HAp possesses poor rheological properties and it is inactive against disease-causing microbes. To improve these properties, we developed a green method to synthesize multifunctional composites containing: (1) cellulose (CEL) to impart mechanical strength; (2) chitosan (CS) to induce antibacterial activity thereby maintaining a microbe-free wound site; and (3) HAp. In this method, CS and CEL were co-dissolved in an ionic liquid (IL) and then regenerated from water. HAp was subsequently formed in situ by alternately soaking [CEL+CS] composites in aqueous solutions of CaCl2 and Na2HPO4. At least 88% of IL used was recovered for reuse by distilling the aqueous washings of [CEL+CS]. The composites were characterized using FTIR, XRD, and SEM. These composites retained the desirable properties of their constituents. For example, the tensile strength of the composites was enhanced 1.9 times by increasing CEL loading from 20% to 80%. Incorporating CS in the composites resulted in composites which inhibited the growth of both Gram positive (MRSA, S. aureus and VRE) and Gram negative (E. coli and P. aeruginosa) bacteria. These findings highlight the potential use of [CEL+CS+HAp] composites as scaffolds in bone tissue engineering. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3266-3277, 2013.
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