期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 101, 期 3, 页码 740-747出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.34376
关键词
hydroxyapatite; dopamine; osteoblasts; osteoconduction; RGD
资金
- National Taiwan University [99R704]
Hydroxyapatite (HAp) coating on orthopedic implants is a common strategy to increase osteointegration. In this work, a facile deposition method based on dopamine polymerization was developed for preparation of HAp-coated titanium substrates for orthopedic applications. Nanostructured HAp was mixed with an alkaline dopamine solution and then deposited onto titanium to form a dopamine/HAp ad-layer. The deposition of dopamine/HAp greatly enhanced the adhesion, proliferation, and mineralization of osteoblasts. Furthermore, RGD-containing peptides were immobilized to dopamine/HAp coated titanium and further enhanced cell adhesion and osteogenic differentiation. In conclusion, this facile dopamine-assisted surface modification method shows a great potential for orthopedic and dental applications. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 740-747, 2013.
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