期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 100A, 期 7, 页码 1803-1814出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.34132
关键词
antimicrobial; biofilm; hydrogel; biomaterials
The effectiveness of the antimicrobial peptide maximin-4, the ultrashort peptide H-Orn-Orn-Trp-Trp-NH2, and the lipopeptide C12-Orn-Orn-Trp-Trp-NH2 in preventing adherence of pathogens to a candidate biomaterial were tested utilizing both matrix- and immersion-loaded poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels. Antiadherent properties correlated to both the concentration released and the relative antimicrobial concentrations of each compound against Staphylococcus epidermidis ATCC 35984, at each time point. Immersion-loaded samples containing C12-Orn-Orn-Trp-Trp-NH2 exhibited the lowest adherence profile for all peptides studied over 1, 4, and 24 h. The results outlined in this article show that antimicrobial peptides have the potential to serve as an important weapon against biomaterial associated infections. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
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