期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 100A, 期 1, 页码 203-210出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.33265
关键词
natural polymer; nanoparticles; hydrophobic interaction; anti-cancer drug; lymphatic chemotherapy
资金
- National Natural Science Foundation of China [20974025, 10979022]
Silk fibroin is a very promising biomedical material because of its renewability, nontoxicity, biocompatibility, and biodegradability. On the basis of a simple and mild method for the preparation of silk fibroin nanospheres with controllable size, the authors developed earlier, anti-cancer drug paclitaxel (PTX)-loaded silk fibroin nanospheres ranging from 270 to 520 nm were produced accordingly. The drug loading, encapsulation efficiency, and released property of PTX-loaded silk fibroin nanospheres are depended on the silk fibroin concentration and initial PTX-loading capacity. The maximum drug loading is about 6.9% and the release time of such a kind of nanospheres is over 9 days. The release time of PTX-loaded silk fibroin nanospheres can be as long as 2 weeks when the drug loading is about 3.0%. All these results imply that such a kind of biomacromolecule-based anti-cancer drug nanocarrier has a great potential for chemotherapy in clinical applications. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A: 203-210, 2012.
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