期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 100A, 期 1, 页码 155-161出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.33255
关键词
smooth muscle cells; alignment; parallel fibers; elastin; electrospinning
资金
- Australian Research Council
- National Health and Medical Research Council
- Australian Postgraduate Award
We generated parallel elastic fibers from synthetic elastin (SE) as a model of the arterial media and assessed the alignment of smooth muscle cells (SMCs). SE utilized crosslinked electrospun human tropoelastin to form aligned fibers that mimicked the topography and elastin-rich content of the medial extracellular matrix. Bundled parallel fibers were anisotropically more elastic than randomly arranged scaffolds (111 +/- 25 kPa vs. 265 +/- 17 kPa) in the direction of the fibers. Aligned and random fiber scaffolds each supported SMC growth. Following attachment, SMCs proliferated longitudinally on the parallel fibers and expressed native alpha-smooth muscle actin. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A: 155-161, 2012.
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