期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 96A, 期 4, 页码 639-647出版社
WILEY
DOI: 10.1002/jbm.a.33017
关键词
chitosan; hydroxyapatite; scaffolds; biodegradation; osteogenesis
Chitosan/hydroxyapatite scaffolds could be used for bone regeneration in case the application of auto-or allografts is impossible. The objective of the present work was to characterize and study in vivo biodegradation of simple chitosan/hydroxyapatite scaffolds. For this purpose, a series of chitosan/hydroxyapatite composites has been synthesized in aqueous medium from chitosan solution and soluble precursor salts by a one step coprecipitation method. A study of in vivo behavior of the materials was then performed using model linear rats. Cylindrical-shaped rods made of the chitosan/hydroxyapatite composite material were implanted into tibial bones of the rats. After 5, 10, 15, and 24 days of implantation, histological and histomorpho-metric analyses of decalcified specimens were performed to evaluate the stages of biodegradation processes. Calcified specimens were examined by scanning electron microscopy with X-ray microanalysis to compare elemental composition and morphological characteristics of the implant and the bone during integration. Porous chitosan/hydroxyapatite scaffolds have shown osteoconductive properties and have been replaced in the in vivo experiments by newly formed bone tissue. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 96A: 639-647, 2011.
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