期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 94A, 期 3, 页码 945-952出版社
WILEY
DOI: 10.1002/jbm.a.32715
关键词
PCL/pHEMA; bone sialoprotein; osseous tissue engineering
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR)
Biomaterials used for tissue engineering scaffolds act as temporary substrates, on which cells deposit newly synthesized extracellular matrix. In cartilage tissue engineering, polycaprolactone/poly(2-hydroxyethyl methacrylate) (PCL/pHEMA) polymer blends have been used as scaffold materials, but their use in osseous tissue engineering has been more limited. The objective of this study was to evaluate modification of PCL/pHEMA surfaces with bone sialoprotein (BSP), an extracellular matrix protein important in regulating osseous tissue formation. Modification of surfaces with BSP significantly enhanced osteoblastic cell attachment and spreading, without compromising proliferation. Thus, BSP-immobilization may be a useful strategy for optimizing scaffolds for skeletal tissue engineering. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 94A: 945-952, 2010
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