期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 96A, 期 1, 页码 132-141出版社
WILEY
DOI: 10.1002/jbm.a.32820
关键词
layer-by-layer; cytocompatibility; hemocompatibility; stent; surface modification
资金
- Major State Basic Research Foundation of China [2005CB623902]
- National Natural Science Foundation of China [NSFC-20774082, 50830106]
- 863 National High-Tech RD Program [2006AA03Z329, 2006AA03Z444]
- Science and Technology Projects of Zhejiang Province [2007C24008]
- National Science Fund for Distinguished Young Scholars [51025012]
Endothelialization and antithrombogenicity are two key issues in stent implantation. The layer-by-layer (LbL) deposition of anticoagulant heparin and cell compatible collagen was explored to develop a multilayered coating with synergic property of antithrombogenicity and fast endothelialization. The quartz crystal microbalance with dissipation (QCM-D), UV spectrometer, spectroscopic ellipsometry, scanning electron microscopy, and confocal laser scanning microscopy investigations indicate that the LbL technique, which based on molecular assembly, provides an easy way to develop a smooth, homogenous, and stable coating onto stents. In vitro blood clotting time tests and the platelet adhesion tests show that the multilayer-modified stents present good hemocompatibility. In vitro endothelial cell (EC) culture results show that the multilayer-modified surfaces accelerate the adhesion and proliferation of ECs. These results illustrate that a stent surface coating with properties of antithrombogenicity and EC preference was obtained via heparin/collagen multilayer modification. This surface coating may have great potential in facilitating in situ endothelialization of blood contacting materials. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 96A: 132-141, 2011.
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