期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 91A, 期 2, 页码 324-330出版社
WILEY
DOI: 10.1002/jbm.a.32211
关键词
chitosan; thermosensitive hydrogels; in situ forming implants; biodegradation; in vivo evaluation
Chitosan is an attractive biopolymer for the preparation of hydrogels. Its unique combination of biocompatibility, biodegradability, bioadhesivity, and tissue-promoting abilities allows pharmaceutical applications. We investigated novel thermosensitive hydrogels based on chitosan homogeneously reacetylated to a deacetylation degree of about 50%, combined with selected polyols or polyoses such as trehalose, a nontoxic polysaccharide. The latter, a gel-inducing and lyoprotective agent enabled the formulation to be lyophilized and rehydrated without affecting the thermosensitive behavior. This made possible long-term storage and promoted its use in a clinical setup. The thermally induced sot-gel transition allowed injectability and in situ setting. Rheological characterization revealed that storage moduli could be increased by one decade by increasing the chitosan concentration from 1.4 to 2.2% (w/w). Evaluation in vivo provided evidence of in situ implant formation in Subcutaneous tissue of Sprague-Dawley rats and permanence for Lip to 3 months. Histopathological analysis demonstrated a mild, chronic, inflammatory reaction that disappeared with the complete absorption of the gel implant over a few months period. Such in situ forming hydrogels could be advantageous for specific applications in drug delivery and tissue engineering. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 324-330, 2009
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