期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 88A, 期 1, 页码 274-280出版社
WILEY
DOI: 10.1002/jbm.a.31924
关键词
gold; in vivo; mechanical test; metal ion release; osseointegration
资金
- The Danish Rheumatism Association
- Helga and Peter Kornings Foundation
- The Orthopedic Research Foundation, Aarhus
- Danish Orthopedic Society
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R29AR042051, R01AR042051] Funding Source: NIH RePORTER
Insertions of orthopedic implants are traumatic procedures that trigger an inflammatory response. Macrophages have been shown to liberate gold ions from metallic gold. Gold ions are known to act in an antiinflammatory manner by inhibiting cellular NF-kappa B-DNA binding and suppressing I-kappa B-kinase activation. The present study investigated whether gilding implant Surfaces augmented early implant osseointegration and implant fixation by its modulatory effect on the local inflammatory response. Ion release was traced by autometallographic silver enhancement. Gold-coated cylindrical porous coated Ti6Al4V implants Were inserted press-fit in the proximal part of tibiae in nine canines and control implants without gold inserted contralateral. Observation time was 4 weeks. Biomechanical push-out tests showed that implant,,, with gold coating had decrease in mechanical strength and stiffness. Histomorphometrical analyses showed gold-coated implants had a decrease in overall total bone-to-implant contact of 35%. Autometallographic analysis revealed few cells loaded with gold close to the gilded implant surface. The findings demonstrate that gilding of implants negatively, affects mechanical strength and osseointegration because of a significant effect of the released gold ions on the local inflammatory process around the implant. The possibility that a partial metallic gold coating could prolong the period of satisfactory mechanical strength, however, cannot be excluded. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 88A: 274-280, 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据