期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 91A, 期 4, 页码 1111-1118出版社
WILEY
DOI: 10.1002/jbm.a.32289
关键词
hydrogel; hyaluronan; injectable; bone tissue engineering; bone morphogenetic protein; polyvinyl alcohol
资金
- The Swedish research council [621-2002-4399]
- Vinnova/Stiftelsen for Strategisk Forsknin [28476-1]
- Stockholm County Council
- Karolinska Institute
Here we present a novel injectable hydrogel which forms a template for de novo formation of bone tissue. Hydrogel formation takes place in situ in less than 1 min by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives. Endogenous cells are recruited in vivo by incorporating bone morphogenetic protein-2 (BMP-2), a powerful promoter for osteogenic differentiation. The hydrogel Was evaluated in vitro by performing a cell viability test and a release study and in vivo by a rat ectopic model. Examination by X-ray, microcomputed tomography, and histology revealed a significant bone formation at the target site for gels containing BMP-2, and a complete degradation was observed for gels without BMP-2 four weeks after injection. There were no signs of inflammation or foreign body response in either group and we believe that this system has the potential as an off-the-shelf injectable to be used where bone tissue is needed. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 1111-1118, 2009
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