期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 91A, 期 4, 页码 1018-1027出版社
WILEY
DOI: 10.1002/jbm.a.32298
关键词
biocompatibility; composite; hydroxyapatite; in vitro; osteoblast cells; polyethylene; polyamide; selective laser sintering
资金
- UK Department of Health's New and Emerging Applications of Technology programme [NEAT E059]
The selective laser sintering (SLS) technique was used to manufacture hydroxyapatite-reinforced polyethylene and polyamide composites as potential customized maxillofacial implants. In vitro tests were carried Out to assess cellular responses, in terms of cell attachment, morphology, proliferation, differentiation, and mineralized nodule formation, using primary human osteoblast cells. This study showed that the SLS composite processed was biocompatible, with no adverse effects observed on cell viability and metabolic activity, supporting a normal metabolism and growth pattern for osteoblasts. Positive von Kossa staining demonstrated the presence of bone-like mineral on the SLS materials. Higher hydroxyapatite content composites enhanced cell proliferation, increased alkaline phosphatase activity, and produced more osteocalcin. The present findings showed that SLS materials have good in vitro biocompatibility and hence demonstrated biologically the potential of SLS for medical applications. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 1018-1027, 2009
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