期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 87A, 期 4, 页码 986-993出版社
WILEY
DOI: 10.1002/jbm.a.31837
关键词
biomaterials; human; mesenchymal stem cells; periodontium; osteogenesis
Recent studies have shown that mesenchymal stein cells obtained from periodontal ligament (PDL-MSCs) are multipotent cells that have similar features of the bone marrow and dental pulp MSCs and are capable of proliferating and producing different types Of tissue Such as bone and tooth associated-tissues. Human PDL-MSCs expanded ex vivo were induced to osteogenesis, seeded in three-dimensional biocompatible scaffolds (fibrin sponge, bovine-derived Substitutes) and examined using light, scanning and transmission electron microscopy. Morphological observations showed extensive growth of cellular biomass partially covering the scaffolds after 4 weeks of incubation in mineralization medium. These finding,, indicate that periodontal ligament can be an easily and efficient autologous source of stein cells with a high expansion capacity and ability to differentiate in osteogenic cells that can colonize and grow connected to bio-compatible scaffold. It can be Suggested that the use of PDL-MSCs for generating graft biomaterials is advantageous for bone tissue engineering in regenerative dentistry. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res S7A: 986-993, 2008
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据