期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 87A, 期 1, 页码 165-175出版社
WILEY
DOI: 10.1002/jbm.a.31752
关键词
superparamagnetic iron oxide nanoparticles; contrast agent; folate; MRI
资金
- National Science Council of the Republic of China [NSC 95-2627-M-037-001]
- National Health Research Institutes [NHRI-EX-95-9424EI]
The surface of superparamagnetic iron oxide nanoparticles (SPIO) with different molecular weight of poly(ethylene glycol) (PEG) and folic acid (FA) were synthesized. The SPIO-PEG-FA nanoparticles are well-dispersed and have good stability in various pH solutions. The lack of hysterestis and remanence at ambient temperatures is characteristic Of superparamagnetic materials for SPIO-PEG-FA. The uptake by macrophage for SPIO-PEG-FA is lower than that of Feridex I.V. even at higher concentration. Internalization of SPIO-PEG-FA in targeted cells (KB cells) was observed by flow-cytometric analysis and in vitro MR imaging. The intensity change of positive KB cell tumor (-20 to 25'%) is significantly lower than that of negative HT-1080 cell tumor from precontrast to postcontrast images of the tumor by in vivo MR imaging. These preliminary results demonstrated that SPIO-PEG-FA have the ability to target folate receptor. (C) 2007 Wiley Periodicals, Inc.
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