期刊
JOURNAL OF BIOMECHANICS
卷 46, 期 11, 页码 1875-1881出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2013.04.027
关键词
Shear wave speed; Nonlinear mechanics; Hepatic pressure; Acoustic radiation force impulse (ARFI)
资金
- NIH [R01 CA-142824, R01 EB-002132, F30 DK095544, R37-H2096023, R21 HD063031]
Elevated hepatic venous pressure is the primary source of complications in advancing liver disease. Ultrasound imaging is ideal for potential noninvasive hepatic pressure measurements as it is widely used for liver imaging. Specifically, ultrasound based stiffness measures may be useful for clinically monitoring pressure, but the mechanism by which liver stiffness increases with hepatic pressure has not been well characterized. This study is designed to elucidate the nonlinear properties of the liver during pressurization by measuring both hepatic shear wave speed (SWS) and strain with increasing pressure. Tissue deformation during hepatic pressurization was tracked in 8 canine livers using successively acquired 3-D B-mode volumes and compared with concurrently measured SWS. When portal venous pressure was increased from clinically normal (0-5 mmHg) to pressures representing highly diseased states at 20 mmHg, the liver was observed to expand with axial strain measures up to 10%. At the same time, SWS estimates were observed to increase from 1.5-2 m/s at 0-5 mmHg (baseline) to 3.25-3.5 m/s at 20 mmHg. (C) 2013 Elsevier Ltd. All rights reserved.
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