期刊
JOURNAL OF BIOMECHANICS
卷 45, 期 5, 页码 805-814出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2011.11.021
关键词
Wall stress; Growth; Remodeling; Finite elements; Hemodynamics
资金
- NIH [R01 HL-086418, R03 EB-010109]
Biomechanical factors play fundamental roles in the natural history of abdominal aortic aneurysms (AAAs) and their responses to treatment. Advances during the past two decades have increased our understanding of the mechanics and biology of the human abdominal aorta and AAAs, yet there remains a pressing need for considerable new data and resulting patient-specific computational models that can better describe the current status of a lesion and better predict the evolution of lesion geometry, composition, and material properties and thereby improve interventional planning. In this paper, we briefly review data on the structure and function of the human abdominal aorta and aneurysmal wall, past models of the mechanics, and recent growth and remodeling models. We conclude by identifying open problems that we hope will motivate studies to improve our computational modeling and thus general understanding of AAAs. (C) 2011 Elsevier Ltd. All rights reserved.
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