期刊
JOURNAL OF BIOMECHANICS
卷 45, 期 10, 页码 1809-1815出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2012.04.017
关键词
Aerosol; Lung; Subject-specific model; Computational mechanics; Drug delivery
资金
- JSPS [23220012, 23360046]
- Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and Research Network Centre
- Grants-in-Aid for Scientific Research [23360046, 23220012] Funding Source: KAKEN
We investigated how breath holding increases the deposition of micrometer particles in pulmonary airways, compared with the deposition during inhalation period. A subject-specific airway model with up to thirteenth generation airways was constructed from multi-slice CT images. Airflow and particle transport were simulated by using GPU computing. Results indicate that breath holding effectively increases the deposition of 5 mu m particles for third to sixth generation (G3-G6) airways. After 10 s of breath holding, the particle deposition fraction increased more than 5 times for 5 mu m particles. Due to a small terminal velocity, 1 mu m particles only showed a 50% increase in the most efficient case. On the other hand, 10 mu m particles showed almost complete deposition due to high inertia and high terminal velocity, leading to an increase of 2 times for G3-G6 airways. An effective breath holding time for 5 mu m particle deposition in G3-G6 airways was estimated to be 4-6 s, for which the deposition amount reached 75% of the final deposition amount after 10 s of breath holding. (C) 2012 Elsevier Ltd. All rights reserved.
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