期刊
JOURNAL OF BIOMECHANICS
卷 43, 期 1, 页码 23-30出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2009.09.005
关键词
Flexural rigidity; Flexibility; Microtubule bundle; Cytoskeletal network
资金
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [0928540] Funding Source: National Science Foundation
Microtubules are rigid cytoskeletal filaments, and their mechanics affect cell morphology and cellular processes. For instance, microtubules for the support structures for extended morphologies, such as axons and cilia. Further, microtubules act as tension rods to pull apart chromosomes during cellular division. Unlike other cytoskeletal filaments (e.g., actin) that work as large networks, microtubules work individually or in small groups, so their individual mechanical properties are quite important to their cellular function. In this review, we explore the past work on the mechanics of individual microtubules, which have. been studied for over a quarter of a century. We also present some prospective on future endeavors to determine the molecular mechanisms that control microtubule rigidity. Published by Elsevier Ltd.
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