期刊
JOURNAL OF BIOMECHANICS
卷 43, 期 3, 页码 500-505出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2009.09.041
关键词
Microrheology; Collagen gels; Self-assembly; Optical tweezers
资金
- Sharman-Fairchild Center
- Center for Optical Technologies at Lehigh University
- NSF [DMR-0421259]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0923299] Funding Source: National Science Foundation
In this paper we report a study where we use a novel optical tweezers technique to measure the local viscoelastic properties of type I collagen solutions spanning the sol-to-gel transition. We use phase contrast optical microscopy to reveal dense and sparse regions of the rigid fibril networks, and find that the spatial Variations ill the mechanical properties of the collagen gels closely follow the structural properties. Within the dense phase of the connected network in the gel samples, there are regions that exhibit drastically different viscoelastic properties. Within the sparse regions of the gel samples, no evidence of elasticity is found. In type I collagen gels, we find a high degree Of Structural inhomogeneity. The inhomogeneity in the structural properties of collagen gels and the corresponding viscoelastic properties provide benchmark measurements for the behavior of desirable biological materials, or tissue equivalents. (C) 2009 Elsevier Ltd. All rights reserved.
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