期刊
JOURNAL OF BIOMECHANICS
卷 41, 期 11, 页码 2589-2596出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2008.05.014
关键词
trabecular; cancellous; voxel; vertebra; nanoindentation; grey values; mu CT
资金
- Irish Research Council for Science, Engineering and Technology (IRCSET)
High-resolution voxel-based finite element software, such as FEEBE developed at the NCBES, is widely used for Studying trabecular bone at the micro-scale. A new approach to determine heterogeneous bone tissue Material properties for computational models was proposed in this study. The specimen-specific range of tissue moduli across strut width was determined from nanoindentation testing. This range was mapped directly using linear interpolation to that specimen's micro-computed tomography (mu CT) grey value range as input material properties for finite element analysis. The method was applied to cuboid trabecular bone samples taken from eight, 4-year-old (skeletally mature) ovine L5 vertebrae. Before undergoing experimental uniaxial compression tests, the samples were mu CT scanned and 30 mu m resolution finite element models were generated. The linear elastic finite element models were compressed to 1% strain. This material property assignment method for computational models accurately reproduced the experimentally determined apparent modulus and concentrations of stress at locations of failure. (C) 2008 Elsevier Ltd. All rights reserved.
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