期刊
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
卷 131, 期 8, 页码 -出版社
ASME
DOI: 10.1115/1.3127250
关键词
biological fluid dynamics; biological tissues; biomedical materials; biomedical ultrasonics; deformation; elasticity; finite element analysis; hydrogels; permeability; porosity; stress relaxation; viscoelasticity
资金
- National Cancer Institute [R0I CA082497]
Ultrasonic elasticity imaging enables visualization of soft tissue deformation for medical diagnosis. Our aim is to understand the role of flow-dependent and flow-independent viscoelastic mechanisms in the response of biphasic polymeric media, including biological tissues and hydrogels, to low-frequency forces. Combining the results of confined and unconfined compression experiments on gelatin hydrogels with finite element analysis (FEA) simulations of the experiments, we explore the role of polymer structure, loading, and boundary conditions in generating contrast for viscoelastic features. Feature estimation is based on comparisons between the biphasic poro-elastic and biphasic poro-viscoelastic (BPVE) material models, where the latter adds the viscoelastic response of the solid polymer matrix. The approach is to develop a consistent FEA material model (BPVE) from confined compression-stress relaxation measurements to extract the strain dependent hydraulic permeability variation and cone-plate rheometer measurements to obtain the flow-independent viscoelastic constants for the solid-matrix phase. The model is then applied to simulate the unconfined compression experiment to explore the mechanics of hydropolymers under conditions of quasi-static elasticity imaging. The spatiotemporal distributions of fluid and solid-matrix behavior within the hydrogel are studied to propose explanations for strain patterns that arise during the elasticity imaging of heterogeneous media.
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