期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 25, 期 12, 页码 1240-1252出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2014.926578
关键词
polypyrole; poly(lactic acid); electrospinning; scaffold; nerve cell
资金
- National Nanotechnology Center (NANOTEC) [RES_54_198_63_006]
- Thailand Research Fund (TRF) [DBG5280015]
Neuronal activities play critical roles in both neurogenesis and neural regeneration. In that sense, electrically conductive and biocompatible biomaterial scaffolds can be applied in various applications of neural tissue engineering. In this study, we fabricated a novel biomaterial for neural tissue engineering applications by coating electrospun poly(lactic acid) (PLA) nanofibers with a conducting polymer, polypyrole (PPy), via admicellar polymerization. Optimal conditions for polymerization and preparation of PPy-coated electrospun PLA nanofibers were obtained by comparing results from scanning electron microscopy, X-ray photoelectron spectrometer, and surface conductivity tests. In vitro cell culture experiments showed that PPy-coated electrospun PLA fibrous scaffold is not toxic. The scaffold could support attachment and migration of neural progenitor cells. Neurons derived from progenitor exhibited long neurite outgrowth under electrical stimulation. Our study concluded that PPy-coated electrospun PLA fibers had a good biocompatibility with neural progenitor cells and may serve as a promising material for controlling progenitor cell behaviors and enhancing neural repair.
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