期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 25, 期 4, 页码 341-353出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2013.861169
关键词
carbon nanofiber; bioglass; eletrospinning
资金
- National Basic Research Program of China [2012CB933900]
- Key Technologies R&D Program of China [2012BAI07B00]
- National High Technology Research and Development Program of China [2011AA030100]
- Beijing municipal Science & Technology Commission Projects [Z121100005212007]
- Key International S&T Cooperation Projects [2011DFA32190]
- Science Foundation of Peking University School and Hospital of Stomatology [YS020212]
Composite nanofibers composed of polyacrylonitrile (PAN)-based carbon nanofibers and bioactive glass (BG) nanoparticles have been prepared by electrospinning and in situ sintering. Morphology observation showed that the BG nanoparticles of size 20-50nm were uniformly distributed on the surface of composite nanofibers with 350nm average diameter after carbonization. Biological mineralization indicated the formation of apatite-like layer on the surface of composite nanofibers, in which the composition of carbonate hydroxyapatite was proved by FTIR and XRD analysis. Cell growth dynamics according to cellular morphology, CCK-8 assay, and alkaline phosphatase activity assay exhibited better cell adhesion, proliferation, and osteogenic induction of bone marrow-derived mesenchymal stem cells cultured on the composite nanofibers, which suggested the higher bioactivity of composite nanofibers compared to pure PAN-based carbon nanofibers.
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