期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 23, 期 1-4, 页码 97-110出版社
TAYLOR & FRANCIS LTD
DOI: 10.1163/092050610X543609
关键词
Silk fibroin sponge; wound dressing; skin defect; therapeutic process
资金
- National Natural Science Foundation of China [30870628]
- Science and Technology Plan Project of Zhejiang Province [2007C2118]
- Program for New Century Excellent Talents in University [NCET070763]
- Program for Qianjiang Talents of Zhejiang Province [2008R10006]
A novel silk fibroin spongy wound dressing (SFSD) incorporated with nano-Ag particles was prepared by coagulating with 1.25-5.0% (v/v) poly(ethylene glycol diglycidyl ether) (PGDE). The mechanical properties, moisture permeability and hygroscopicity of SFSD, and the nano-Ag release behavior from SFSD were evaluated. The results showed that the soft SFSD had satisfying tensile strength and flexibility, as well as excellent moisture permeability and absorption capability of wound exudates. The moisture permeability was 101 g/m(2) per h and the water absorption capacity of SFSD was 595.2% and 251.9% of its own weight in dry and wet states, respectively. The nano-Ag in the SFSD was released continuously at a relatively stable rate in PBS resulting in a remarkable antibacterial property. A rabbit model was used to dynamically observe the healing process of full-thickness skin defects. Full-thickness wounds were created on the dorsal side of rabbits, which were covered with SFSD and porcine acellular dermal matrix (PADM) for comparison. The mean healing time of the wounds covered with SFSD was 17.7 +/- 2.4 days, significantly shorter than that with PADM. The histological analysis showed that the epidermal cell layer formed with SFSD was very similar to normal skin, suggesting that SFSD may provide a good component for the development of new wound dressings. (C) Koninklijke Brill NV, Leiden, 2012
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据