期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 23, 期 7, 页码 643-648出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2015.6327
关键词
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资金
- Foundation Fighting Blindness, Columbia, MD from National Eye Institute [EY05951]
- Foundation Fighting Blindness Clinical Research Institute (FFB CRI)
- U.S. Department of Defense USAMRMC TATRC, Fort Meade, MD [W81-XWH-07-1-0720, W81XWH-09-2-0189]
- The Shulsky Foundation (New York, NY)
- Ocular Albinism Research Fund (Clark Enterprises, Inc., Bethesda, MD)
- Research to Prevent Blindness
- Baylor-Johns Hopkins Center for Mendelian Genetics (National Human Genome Research Institute, NHGRI/NIH) [1U54HG006542-01]
- Austrian Scientific Funds (FWF) [J3383-B23]
Retinitis pigmentosa (RP) is a group of diseases in which a mutation in one of the large variety of genes causes death of rod photoreceptors. After rods die, cone photoreceptors gradually die resulting in constriction of visual fields and eventual blindness in many patients. Studies in animal models of RP have demonstrated that oxidative damage is a major contributor to cone cell death. In this study, we extended those findings to patients with RP, because compared to control patients, those with RP showed significant reduction in the reduced to oxidized glutathione (GSH/GSSG) ratio in aqueous humor and a significant increase in aqueous protein carbonyl content. In contrast, there was no significant decrease in the serum GSH/GSSG ratio or increase in carbonyl content of serum proteins. These data indicate that patients with RP have ocular oxidative stress and damage in the absence of manifestations of systemic oxidative stress and/or damage indicating that demonstrations of oxidative damage-induced cone cell death in animal models of RP may translate to human RP. These observations lead to the hypothesis that potent antioxidants will promote cone survival and function in patients with RP and that the aqueous GSH/GSSG ratio and carbonyl content on proteins may provide useful biomarkers. Antioxid. Redox Signal. 23, 643-648.
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