期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 22, 期 8, 页码 1023-1033出版社
TAYLOR & FRANCIS LTD
DOI: 10.1163/092050610X497881
关键词
Nanocomposite hydrogel; wound dressing; in vivo test; cytotoxicity; poly(vinyl alcohol)
资金
- Tarbiat Modares University
In the present work, a nanocomposite hydrogel wound dressing was prepared on the basis of poly(vinyl alcohol) using organically-modified montmorillonite as nanoclay by the freezing thawing cyclic method. In vivo assays were performed to evaluate its performance as an applicable wound dressing on animals. It showed an improved healing process for wounds covered by the prepared nanocomposite hydrogel compared with control wounds covered by sterile gauze. Significant improvements, such as better creation of moist surfaces on the wound with less scar formation, shorter duration of healing operation and better closing of the wound edges with enhanced tensile properties of the healed wound, i.e., tensile strength and elongation-at-break, were observed using the prepared nanocomposite hydrogel in comparison to the sterile gauze. An in vitro cytotoxic assay was also utilized to determine the biocompatibility of the prepared nanocomposite hydrogel. It showed that the prepared nanocomposite hydrogel is non-toxic and can be used as a biocompatible wound dressing in practical wound management. (c) Koninklijke Brill NV, Leiden, 2011
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据