期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 22, 期 1-3, 页码 59-75出版社
TAYLOR & FRANCIS LTD
DOI: 10.1163/092050609X12578498952315
关键词
Thermo-responsive hydrogel; poly(N-isopropylacrylamide); poly(ethylene glycol); protein release; drug delivery
资金
- The Lincy Foundation
- The Macula Foundation
- Veteran's Administration
- National Science Foundation [0852048]
- Div Of Engineering Education and Centers
- Directorate For Engineering [0852048] Funding Source: National Science Foundation
Thermo-responsive hydrogels have shown promise as injectable materials for local drug delivery. However, the phase-induced changes in polymer properties of N-isopropylacrylamide (NIPAAm) can pose additional challenges for achieving controlled protein release. In this work, thermo-responsive hydrogels derived from NIPAAm and cross-linked with poly(ethylene glycol) diacrylate (PEG-DA) were synthesized via free radical polymerization. The volume phase transition temperature (VPTT) of the hydrogels ranged from 32.9 degrees C to 35.9 degrees C. Below the VPTT, swelling ratios of the hydrogels decreased with cross-linker concentration, and showed a sharp drop (at least 4-fold) upon phase change. Protein encapsulation efficiency was high (84-90%) and decreased with cross-linker concentration. Release of bovine serum albumin, a model protein, at body temperature was significantly higher than at room temperature (67% at 37 degrees C compared to 44% at 23 degrees C after 48 h). The release kinetics of proteins from the hydrogels were initially expected to be a function of cross-link density. However, at the hydrogel compositions explored in this work, protein release did not change significantly with cross-linker mol fraction. The thermo-responsive hydrogels offer a promising platform for the localized delivery of proteins. (C) Koninklijke Brill NV, Leiden, 2011
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