期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 28, 期 6, 页码 837-848出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328213483842
关键词
Chondrocyte; osteoblasts; biodegradable polymers; dopamine; mineralization; cell attachment and proliferation
资金
- National Science Council, Taiwan [100-2221-E-002-114-MY2]
In this study, a technique based on poly(dopamine) deposition to promote cell adhesion was investigated for the application in bone tissue engineering. The adhesion and proliferation of rat osteoblasts were evaluated on poly(dopamine)-coated biodegradable polymer films, such as polycaprolactone, poly(l-lactide) and poly(lactic-co-glycolic acid), which are commonly used biodegradable polymers in tissue engineering. Cell adhesion was significantly increased to a plateau by merely 15s of dopamine incubation, 2.2-4.0-folds of increase compared to the corresponding untreated substrates. Cell proliferation was also greatly enhanced by poly(dopamine) deposition, indicated by shortened cell doubling time. Mineralization was also increased on the poly(dopamine)-deposited surfaces. The potential of poly(dopamine) deposition in bone tissue engineering is demonstrated in this study.
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