期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 28, 期 2, 页码 288-297出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328212446097
关键词
Biodegradable poly(D; L-lactic acid) microspheres; poly(ethylene glycol)-poly(-caprolactone)-poly(ethylene glycol) hydrogel; dexamethasone; injectable hydrogel composite; orthopedic tissue engineering
资金
- New Century Excellent Talents in University [NCET-08-0371]
- Sichuan Key Project of Science and Technology [2011SZ0219]
The corium is decreased to about half of its thickness in skin defects and wrinkles due to gravity and environment. In this study, dexamethasone/poly(d,l-lactic acid) (Mn=160,000) microspheres were incorporated into poly(ethylene glycol)-poly(-caprolactone)-poly(ethylene glycol) (Mn=3300) hydrogel to prepare an injectable hydrogel composite. The composite was designed to increase the thickness of the corium. Dexamethasone/poly(d,l-lactic acid) microspheres were prepared by oil-in-water emulsion/solvent evaporation technique. The properties of microspheres were investigated by size distribution measurement, scanning electron microscope and x-ray diffraction. Drug loading, encapsulation efficiency, and drug delivery behavior of microspheres were also studied in detail. Cell adhesion of microspheres was investigated by NIH3T3 cell invitro. The properties of hydrogel composite were investigated by scanning electron microscope, rheological measurements and methyl thiazolyl tetrazolium assay. Drug release from composite was determined by HPLC-UV analysis. These results suggested that poly(d,l-lactic acid) microspheres encapsulating dexamethasone embedded in poly(ethylene glycol)-poly(-caprolactone)-poly(ethylene glycol) hydrogel might have prospective application in orthopedic tissue engineering field.
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