期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 27, 期 3, 页码 333-344出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328211405246
关键词
Self-assembly; supramolecular Hydrogel; micelles; drug delivery; monoend-functionalized
资金
- National Basic Research Program of China (National 973 program) [2011CB606206]
- National Science Foundation of China (NSFC) [20604016, 50830105]
- Sichuan Youth Science & Technology Foundation [07ZQ026-013]
- Open Fund of Engineering Research Center of Biomass Materials, Ministry of Education [2010LF4002]
An effective strategy was developed to fabricate a supramolecular hydrogel with the complexation of alpha-cyclodextrins (alpha-CDs) and monoend-functionalized low molecular weight methoxy poly(ethylene glycol) (mPEG, Mn=2000) micelles. Hydrophobic cinnamic acid was immobilized on methoxy poly(ethylene glycol) via L-lysine as linker to prepare amphiphilic mPEG. The monoend-functionalized mPEG self-assembled micelles in aqueous solution. The size and size distribution of the micelles were tested by dynamic laser scattering (DLS). The morphology of the micelles was observed by SEM, TEM and AFM. The critical micelle concentration (CMC) was tested and it was 42.5 mg/L. The monodisperse micelles had core-shell structure and the mean diameter was around 40 nanometers. alpha-cyclodextrins were added in the suspension of micelles to form supramolecular hydrogel with the polypseudorotaxanes complexation. Hydrophilic drug doxorubicin hydrochloride was used as model drug to study the release profile. The results showed that the hydrogel was a promising carrier for drug delivery.
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