期刊
JOURNAL OF BIOLOGICAL PHYSICS
卷 35, 期 1, 页码 43-55出版社
SPRINGER
DOI: 10.1007/s10867-009-9129-0
关键词
Energy transfer; Proteins; VES hypothesis; Amide I band; Temperature dependence
类别
资金
- Foundation for Science and Technology
The current status of the Davydov/Scott model for energy transfer in proteins is reviewed. After a brief introduction to the theoretical framework and to the basic results, the problems of finite temperature dynamics and of the full quantum and mixed quantum-classical approximations are described, as well as recent results obtained within each of these approximations. A short survey of experimental evidence in support of the Davydov/Scott model is made and absorption spectra are calculated that show the same temperature dependence as that measured in crystalline acetanilide. Future applications of the Davydov/Scott model to protein folding and function and to misfolding diseases are outlined.
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