期刊
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
卷 16, 期 5, 页码 715-724出版社
SPRINGER
DOI: 10.1007/s00775-011-0772-0
关键词
Chemotherapeutics; Bioorganometallic chemistry; Mitochondria; Ruthenium; Reactive oxygen species
资金
- Indo Swiss Bilateral Research Initiative (EPFL)
The organometallic glutathione S-transferase inhibitor ruthenium(II) (ethacrynic acid-eta(6)-benzylamide)(1,3,5-triaza-7-phosphaadamantane) dichloride, termed ethaRAPTA, has been demonstrated to induce apoptosis in the cisplatin-resistant MCF-7 breast cancer cell line. Probing the molecular basis of this activity suggests that the complex triggers multiple pathways toward apoptosis, including those involving endonuclease G, caspases, and c-Jun N-terminal kinase, which could provide a therapy for multi-drug-resistant tumors. Furthermore, the induction of heat shock protein 70 expression enhances selectivity of the complex for tumor cells, reducing the general toxicity.
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